调控肿瘤微环境实现血管正常化的研究进展

Research Progress in the Regulation of Tumor Microenvironment for Vascular Normalization

异常肿瘤血管导致低氧、低pH的恶性微环境形成,加剧肿瘤恶化、机体免疫抑制和治疗耐药,肿瘤血管已成为治疗的重要靶点。传统的抗血管生成疗法由于容易产生耐药仍存在争议。基于此,有学者提出肿瘤血管的正常化理论,即肿瘤血管生成回到更成熟和稳定的血管系统。肿瘤微环境(TME)在微血管的启动和发展中起着重要的作用。近年来,许多研究致力于通过TME提高肿瘤微血管正常化治疗效果。本文综述了基于肿瘤微环境在血管正常化中的靶向和重塑策略最新研究进展,并对其中存在的问题及未来的发展进行讨论。

Abnormal tumor blood vessels lead to the formation of a malignant microenvironment with low ox-ygen and low pH, which aggravates tumor deterioration, immunosuppression and drug resistance. Tumor blood vessels have become an important target for treatment. Traditional anti- angiogenesis therapy is still controversial due to drug resistance. Based on this, some scholars have proposed the normalization theory of tumor blood vessels, that is, to achieve tumor angiogenesis back to a more mature and stable vascular system. Tumor microenvironment (TME) plays an important role in the initiation and development of microvessels. In recent years, many studies have focused on improv-ing the therapeutic effect of tumor microvascular normalization by TME. This article reviews the latest research progress of targeting and remodeling strategies based on tumor microenvironment in vascular normalization, and discusses the existing problems and future development.