2%克立硼罗软膏治疗轻中度特应性皮炎安全性和有效性的Meta分析

Efficacy and Safety of 2% Crisaborole Ointment for Mild to Moderate Atopic Dermatitis: A Meta-Analysis

目的:系统性评价2%克立硼罗(Crisaborole)软膏治疗轻中度特应性皮炎(AD)的有效性与安全性。方法:检索中国知网、维普、万方、Embase、Cochrane Library、PubMed和ClinicalTrials.gov 7个数据库,从其中筛选出有关2%克立硼罗软膏治疗轻中度特应性皮炎的临床研究。对相关研究进行数据筛选和偏倚风险评估。使用RevMan5.4软件对筛选出的数据进行系统性荟萃分析。结果:7项随机对照临床试验被筛选入该项研究中,共包括2174例AD患者。Meta分析结果显示,2%克立硼罗治疗特应性皮炎的疗效优于赋形剂具有统计学意义。外用2%克立硼罗软膏的不良反应及严重不良反应发生率与赋形剂相比,其差异没有统计学意义。结论:2%克立硼罗软膏用于治疗轻中度特应性皮炎有效性良好。2%克立硼罗软膏的安全性良好。

Objective: To systematically evaluated the safety and efficacy of 2% Crisaborole ointment in the treatment of mild to moderate atopic dermatitis (AD). Methods: Seven databases including China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Wanfang data-base, Embase, CochraneLibrary, PubMed and ClinicalTrials.Gov. were searched to screen out clinical studies related to clariborol in the treatment of atopic dermatitis, and data extraction and bias risk assessment were conducted for the selected studies. Finally, a systematic meta-analysis of the ex-tracted data was conducted using RevMan5.4 software. Results: Seven randomized controlled clini-cal trials were screened for the study, involving a total of 2174 patients with AD. The results of the meta-analysis showed that the efficacy of 2% creborol in the treatment of atopic dermatitis was sta-tistically superior to excipients. There was no statistical significance in the incidence of adverse re-actions and serious adverse reactions of 2% creborol ointment compared with excipients. Conclu-sion: 2% Crisaborole ointment is effective for the treatment of mild to moderate AD. The safety of 2% Crisaborole ointment is good.