食管癌患者放疗时行营养干预后的相关指标变化研究进展

Research Progress on Changes of Related Indexes after Nutritional Intervention in Patients with Esophageal Cancer Undergoing Radiotherapy

食管癌在我国的发病率逐年上升,是常见的消化道肿瘤之一,严重威胁我国人民的生命健康。由于食管癌早期症状不典型,很少在早期引起患者注意,就诊时往往已是晚期,又因为进食困难及肿瘤自身的消耗,食管癌患者往往伴有程度不一的营养不良。放射治疗作为中晚期无法手术治疗的患者的首要治疗方式,在进行放射治疗时引发的放射性反应,也会加重食管梗阻及进食苦难,造成营养不良。营养不良继而加重肿瘤消耗,多项研究更是证明其影响免疫功能,进而影响食管癌患者预后及生存质量,而适当的营养干预会缓解患者的营养不良,并且能够延缓免疫功能的降低速度。本综述整理收集近几年的相关研究,对食管癌患者放疗时行营养干预后的相关指标进行探讨。

The incidence of esophageal cancer in China increases year by year, and it is one of the common gastrointestinal tumors, which seriously threatens the life and health of our people. Because the early symptoms of esophageal cancer are atypical and rarely attract the attention of patients in the early stage, patients with esophageal cancer are often in the advanced stage at the doctor’s visit, and because of eating difficulties and the consumption of the tumor itself, patients with esophageal cancer are often accompanied by malnutrition to varying degrees. Radiation therapy is the primary treatment for patients in the advanced stage who cannot be treated surgically. The radioactive re-action caused by radiation therapy can also aggravate esophageal obstruction and eating hardship, resulting in malnutrition. Malnutrition then aggravates tumor consumption. Many studies have proved that malnutrition affects immune function, further affecting prognosis and life quality of pa-tients with esophageal cancer. Appropriate nutrition intervention can alleviate malnutrition of pa-tients and delay the decline rate of immune function. This review collects the relevant studies in recent years, and discusses the relevant indicators of patients with esophageal cancer after nutri-tional intervention during radiotherapy.