抗生素骨水泥治疗感染创面研究进展

Research Progress of Antibiotic-Loaded Bone Cement in Treating Infected Wounds

感染是创面愈合过程中最严重的并发症之一。创面感染后可使创面延迟愈合或不愈合,若感染未能得到有效控制,则极易形成慢性难愈性创面,甚至可导致全身感染从而危及生命。国内外近年来应用骨水泥作为抗生素的载体来治疗感染创面逐渐成为主流。抗生素骨水泥(Antibiotic-loaded bone cement, ALBC)具有局部抗感染作用、促进创面愈合、减少患者手术次数、住院时间及住院费用等生活负担等优点。本综述对ALBC治疗感染创面的机制、抗生素的选择、安全性与毒性及临床治疗效果进行总结,为感染创面的治疗提供参考。

Infection is one of the most serious complications in the process of wound healing. Infection of the wound can cause delayed healing or non-healing of the wound, and if the infection is not effectively controlled, it is very likely to form a chronic refractory wound, which can even lead to systemic in-fection and thus endanger life. The application of bone cement as a carrier of antibiotics to treat in-fected wounds has gradually become mainstream in recent years both domestically and interna-tionally. Antibiotic-loaded bone cement (ALBC) has the advantages of local anti-infective effects, promoting wound healing, and reducing the burden of living such as the number of surgeries, length of hospital stay, and hospital costs for patients. This review summarizes the mechanisms, an-tibiotic selection, safety and toxicity, and clinical outcomes of ALBC for the treatment of infected wounds.