miR-125a-5p与肺结核关系的研究进展

Research Progress on the Relationship between miR-125a-5p and Pulmonary Tuberculosis

肺结核(pulmonary tuberculosis, PTB)指的是由结核分枝杆菌引发的肺部感染性疾病,是严重威胁人类健康的疾病。结核分枝杆菌感染后绝大多数感染者处于结核分枝杆菌潜伏感染(Latent tuberculo-sis infection, LTBI)状态,5%~10%的LTBI者一生中会发展为活动性结核病。miR-125a-5p是一种微小RNA分子亚型,研究显示miR-125a-5p对肺结核的发生发展及转归具有重要作用。本文介绍了miR-125a-5p调控巨噬细胞极化及炎症反应,总结了miR-125a-5p与肺结核的关联性,认为miR-125a-5p对肺结核患者的诊治有一定指导意义。

Tuberculosis (pulmonary tuberculosis, PTB) refers to the pulmonary infectious disease caused by Mycobacterium tuberculosis, which is a serious threat to human health disease. After mycobacte-rium tuberculosis infection, the vast majority of infected people are in the latent mycobacterium tuberculosis infection (Latent tuberculosis infection, LTBI) status, and 5% to 10% of LTBI patients will develop active TB during their lifetime. As miR-125a-5p is a tiny RNA molecular subtype, stud-ies showed that miR-125a-5p plays an important role in the development and outcome of pulmo-nary tuberculosis. This paper introduces the regulation of macrophage polarization by miR-125a-5p and inflammatory response, summarizes the association of miR-125a-5p and pulmonary tuberculo-sis, and believes that miR-125a-5p has some guidance for the diagnosis and treatment of pulmo-nary tuberculosis patients.