钙敏感受体在骨肉瘤中的研究进展

Research progress of Calcium Sensing Receptors in Osteosarcoma

骨肉瘤(osteosarcoma, OS)是来源于间充质的恶性骨肿瘤,常侵犯长骨的干骺端,特别是股骨远端和胫骨近端,并易于血行肺转移。随着新辅助化疗的进步,OS患者5年内生存率虽然有所改善,但其远期治疗效果仍不理想,复发转移是OS治疗失败的重要原因。钙敏感受体(CaSR)属于G蛋白耦联受体家族成员,在维持钙离子和细胞内稳态,以及调节多种细胞增殖、分化、细胞凋亡和激素分泌等方面发挥重要作用。CaSR可通过激活或抑制机制为OS的治疗提供新的途径。

Osteosarcoma (OS) is a malignant bone tumor originating in the mesenchyme, which frequently damages the metaphysis of long bones, especially in the distal femur and proximal tibia, but also predisposes to blood to lung metastasis. Although patients’ survival has improved in all five years with the advance of neoadjuvant chemotherapy technology, the long-term outcome is unsatisfacto-ry. Because calcium-sensing receptor (CaSR) is an important component of G-protein-coupled re-ceptors, it plays a pivotal role in protecting cells from calcium ions, cell stability, cell growth, differ-entiation, apoptosis, and hormone production. CaSR will open a whole new road to the development of OS, whether by activating or inhibiting mechanisms.