自身免疫性脑炎相关痫性发作研究进展

Research Progress in Epileptic Seizures Associated with Autoimmune Encephalitis

癫痫的发病原因复杂,包括遗传、中毒、代谢、感染、以及结构的改变,其中自身免疫性是最常见的原因之一。近年来随着对自身免疫性脑炎认识的加深,临床上越来越多的患者被明确诊断。通常伴有严重的癫痫发作和癫痫持续状态。本文就抗NMDAR、LGI1和GABABR脑炎等临床常见的自身免疫性脑炎相关痫性发作的发病机制和临床特征研究进展进行综述,提高对自身免疫性脑炎相关痫性发作疾病的认识,为临床医生诊断和治疗提供参考价值。

The causes of epilepsy are complex, including genetics, poisoning, metabolism, infection, and struc-tural changes, among which autoimmune is one of the most common causes. In recent years, with the deepening of the understanding of autoimmune encephalitis, more and more patients have been diagnosed clinically. It is usually accompanied by severe seizures and continued seizures. This article reviews the progress in the pathogenesis and clinical features of anti-epileptic seizures asso-ciated with autoimmune encephalitis, such as NMDAR, LGI1and GABABR encephalitis, to improve the understanding of epileptic seizures associated with autoimmune encephalitis and provide ref-erence for the diagnosis and treatment of clinicians.