西宁地区KL-6联合肺间质纤维化CT评分对特发性肺纤维化的诊断价值

Diagnostic Value of KL-6 Combined with CT Score of Pulmonary Interstitial Fibrosis in Xining Area for Idiopathic Pulmonary Interstitial Fibrosis

特发性肺纤维化是原因不明的以普通型间质性肺炎为特征性病理表现的慢性、进行性发展的、预后较差的间质性肺疾病,目前尚缺乏有效的、灵敏度高的无创监测指标。涎液化糖链抗原(KL-6)可反映肺泡损伤,与健康人群对比有显著差异,且KL-6与肺间质纤维化评分有显著正相关,两者联合对于特发性肺间质纤维化具有良好诊断价值。本文拟观察西宁地区特发性肺间质纤维化患者KL-6联合肺间质纤维化评分对该病诊断的临床应用价值。

Idiopathic interstitial lung fibrosis is a chronic, progressive, poorly prognostic interstitial lung dis-ease of unknown cause with common type interstitial pneumonia as the characteristic pathological manifestation, and there is a lack of adequate and sensitive noninvasive monitoring indicators. Sal-ivary liquefied glycocalyx antigen (KL-6) can reflect alveolar damage, and there is a significant dif-ference in comparison with a healthy population. There is a significant positive correlation between KL-6 and interstitial lung fibrosis score, and the combination of the two has a good diagnostic value for idiopathic interstitial lung fibrosis. In this paper, we intend to observe the clinical application value of KL-6 combined with interstitial fibrosis score for the diagnosis of idiopathic interstitial pulmonary fibrosis in the Xining area.