食管癌的免疫治疗研究进展

Research Progress in Immunotherapy of Esophageal Cancer

食管癌不论是在国内,还是在国际上均为最常见的恶性肿瘤之一。食管癌因为其早期往往可能无任何明显症状,患者发现时已经进入中晚期,导致总体预后较差。临床上,食管癌的治疗方式因受浸润程度、发生位置、病理分型、有无转移、科技技术发展、医师和医疗机构的经验,以及患者身体条件、接受程度等因素的影响,使其治疗方式千差万别。随着各个领域得不断进步,近几年,免疫检查点抑制剂作为一种新的食管癌治疗手段,取得了显著的疗效。现本文查阅了近期发表的食管癌免疫治疗相关实验及文献,围绕食管癌的免疫研究治疗进展进行综述。

Esophageal cancer is one of the most common malignant tumors both domestically and interna-tionally. Because esophageal cancer may not have any obvious symptoms in its early stage, the pa-tient has already entered the middle and late stage when it is discovered, resulting in a poor overall prognosis. Clinically, the treatment methods of esophageal cancer vary greatly due to factors such as the degree of invasion, location of occurrence, pathological type, presence or absence of metastasis, technological development, experience of doctors and medical institutions, as well as patients’ physical conditions and acceptance. Despite continuous progress in various fields, in recent years, immune checkpoint inhibitors, as a new treatment for esophageal cancer, have achieved remarka-ble efficacy. Now this article consults the recently published experiments and literatures related to immunotherapy of esophageal cancer, and summarizes the progress of immune research and treatment of esophageal cancer.