SphK1和微炎症状态在慢性肾脏病中的作用

The Role of SphK1 and Micro-Inflammation in Chronic Kidney Disease

鞘氨醇激酶1 (Sphingosine Kinase-1, SphK1)是一种广泛存在的脂类激酶,在生物体内参与生长、分化、增殖、凋亡及调节炎症反应等多种病理生理过程。微炎症状态是指炎症因子持续轻度增高的一种无显性感染的炎症状态。目前已证实SphK1、微炎症状态和慢性肾脏病(Chronic Kidney Disease, CKD)均有着密切关系,因此SphK1、微炎症状态在CKD中的作用受到人们越来越多的关注。本文就SphK1和微炎症状态在CKD中的作用研究现状进行综述,重点介绍SphK1、微炎症状态在CKD发生发展中的作用以及SphK1、微炎症状态之间的相互关系。

Sphingosine Kinase-1 (SphK1) is a ubiquitous lipid kinase that participates in various pathophysio-logical processes such as growth, differentiation, proliferation, apoptosis and regulation of inflam-matory response in organisms. The micro-inflammatory state refers to an inflammatory state with-out dominant infection in which inflammatory factors continue to increase slightly. It has been con-firmed that SphK1, micro-inflammatory state and chronic kidney disease (CKD) are closely related, so the role of SphK1 and micro-inflammatory state in CKD has attracted more and more attention. This article reviews the role of SphK1 and microinflammatory state in CKD, focusing on the role of SphK1 and microinflammatory state in the development of CKD and the relationship between SphK1 and microinflammatory state.