红细胞分布宽度在原发性胆汁性胆管炎中的评估价值

Evaluation Value of Red Blood Cell Distribution Width in Primary Biliary Cholangitis

原发性胆汁性胆管炎(primary biliary cholangitis, PBC)是一种自身免疫介导的慢性胆汁淤积性肝病,病因尚未被明确,若不尽早诊治则预后较差,肝穿刺活检是该病常用的临床诊断方法,但其为有创检查,且结果易受多种因素的影响,因此,人们一直在寻找一种廉价、容易获得、非侵入性的标志物来帮助监测PBC。近年来,大量临床研究证实红细胞分布宽度在原发性胆汁性胆管炎病情评估中发挥重要作用,本文就原发性胆汁性胆管炎与红细胞分布宽度的研究进展作一概述。

Primary biliary cholangitis (PBC) is an autoimmune mediated chronic cholestatic liver disease with unclear etiology and poor prognosis if not diagnosed and treated early. Liver biopsy is a commonly used clinical diagnostic method for this disease, but it is an invasive examination and the results are easily influenced by multiple factors. Therefore, people have been searching for cheap, easily ob-tainable noninvasive biomarkers to assist in monitoring PBC. In recent years, a large number of clinical studies have confirmed that the distribution width of red blood cells plays an important role in the evaluation of the condition of primary biliary cholangitis. This article provides an overview of the research progress on primary biliary cholangitis and the distribution width of red blood cells.