FeNO在检测COPD和哮喘-COPD (ACO)的研究进展

Research Progress on FeNO in Detecting COPD and Asthma COPD (ACO)

呼出气一氧化氮(FeNO)是近年来发展起来的一项新的定量、非侵入性、简便安全的气道炎症检测技术,已被广泛用于临床检测以嗜酸性粒细胞浸润为主的气道炎症,反映气道炎症状态以及预测对激素治疗的反应性等。因其与嗜酸粒细胞气道炎症密切相关而广泛用于支气管哮喘研究,值得关注的是,近年研究发现,FeNO与COPD和ACO患者的慢性气道炎症相关,他们之间最大的共同点就是存在不同程度的气道炎症,虽然已开展了一些初步研究,但现有研究结论存在诸多争议和冲突,探究FeNO检测在气道炎症性疾病中的作用可能是未来研究趋势。

Exhaled nitric oxide (FeNO) is a new quantitative, non-invasive, simple and safe airway inflamma-tion detection technique developed in recent years, which has been widely used in clinical detection of airway inflammation mainly characterized by eosinophil infiltration, reflecting the status of air-way inflammation and predicting the responsiveness to hormone therapy. It is widely used in bronchial asthma studies due to its close correlation with eosinophilic airway inflammation. It is noteworthy that FeNO has been found in recent years to be associated with chronic airway inflam-mation in COPD and ACO patients. The biggest common point between FENO and ACO patients is the existence of airway inflammation to varying degrees. However, there are many disputes and con-flicts in the existing research conclusions, so it may be a future research trend to explore the role of FeNO detection in airway inflammatory diseases.