维持性血液透析患者血清25(OH)D与难治性高血压的相关分析

Correlation Analysis between Serum 25(OH)D and Refractory Hypertension in Maintenance Hemodialysis Patients

难治性高血压在维持性血液透析患者中非常常见,严重威胁患者的预后和生活质量。其发病机制复杂,研究发现血清25(OH)D与难治性高血压相关,维生素D通过抑制肾素基因表达、调节微炎症状态等与血液透析患者难治性高血压相关,为难治性高血压的治疗提供了新思路。

Refractory hypertension is very common in maintenance hemodialysis patients and seriously threatens their prognosis and quality of life. Its pathogenesis is complex, and studies have found that serum 25(OH)D is related to refractory hypertension. Vitamin D is related to refractory hyper-tension by inhibiting renin gene expression and regulating the microinflammatory state of hemodi-alysis patients, which provides a new idea for the treatment of refractory hypertension.