1p缺失在多发性骨髓瘤中的研究进展

Research Progress of 1p Deletion in Multiple Myeloma

多发性骨髓瘤(MM)是终末分化的B细胞恶性肿瘤,被广泛认为是无法治愈的,因为许多患者要么产生了耐药性,要么最终复发。为了制定精确有效的治疗策略,我们必须了解MM的发病机制。在本综述中,我们描述了一些肿瘤抑制因子在1p缺失中丢失或下调,总结了它们的生物学功能及其在MM发病机制中的作用,希望发现潜在的治疗靶点,促进未来治疗方法的发展。

Multiple myeloma (MM) is a terminally differentiated B-cell malignancy that is widely considered incurable because many patients either develop drug resistance or eventually relapse. In order to develop accurate and effective treatment strategies, we must understand the pathogenesis of MM. In this review, we describe the loss or down-regulation of some tumor suppressors in 1p deletion, summarize their biological functions and their roles in the pathogenesis of MM, and hope to find potential therapeutic targets and promote the development of future treatment methods.