肠道菌群在急性髓系白血病中的研究进展

Advances in the Study of Intestinal Flora in Acute Myeloid Leukemia

急性髓系白血病是一种起源于造血干细胞/祖细胞的恶性克隆性疾病,是成人白血病中最常见的类型。肠道菌群是人体微生物最大、最复杂群落,与人体的正常的生命活动、内环境的稳定及免疫系统密切相关。研究发现,肠道菌群与AML之间存在相互作用。近年来研究发现,肠道菌群通过多种机制影响AML的发生,并与其治疗、预后及预防均有着密切的关系。本文就肠道菌群对AML的发生、治效及预后的影响及相关机制进行综述,旨在为AML的治疗和预防提供新思路。

Acute myeloid leukemia is a malignant clonal disease that originates from hematopoietic stem/pro genitor cells and is the most common type of adult leukemia. The intestinal flora is the largest and most complex community of microorganisms in the human body, and is closely related to the nor-mal life activities, stability of the internal environment and immune system. It has been found that there is an interaction between intestinal flora and AML. Recent studies have found that intestinal flora affects the occurrence of AML through various mechanisms, and has a close relationship with its treatment, prognosis and prevention. In this paper, we review the effects of intestinal flora on the occurrence, treatment and prognosis of AML and the related mechanisms, aiming to provide new ideas for the treatment and prevention of AML.