摘要
炎症之于机体是一把双刃剑,适度的炎症反应利于机体对抗外界病原微生物的感染,而失调的炎症反应又会使这把利剑挥向机体自身,过度放大或持续存在的炎症反应是导致机体组织损伤和器质性病变的主要原因。在多种机制中,低度炎症对于胰岛素抵抗的发展至关重要,这是2型糖尿病的一个特征。含有NLRP3炎性小体与各种组织中胰岛素抵抗的发展有关,本文就NLRP3炎症小体在胰岛素抵抗中的作用及相关机制进行阐述。
Inflammation is a double-edged sword for the body. A moderate inflammatory response is condu-cive to the body’s resistance to infection by external pathogenic microorganisms, while an unbal-anced inflammatory response will make the sword swing towards the body itself. Over-amplified or persistent inflammatory response is the main cause of tissue damage and organic diseases. Among a variety of mechanisms, low-grade inflammation is critical for the development of insulin re-sistance, a feature of type 2 diabetes. The presence of NLRP3 inflammasome is associated with the development of insulin resistance in various tissues. In this paper, the role of NLRP3 inflammasome in insulin resistance and related mechanisms were discussed.
出处
《临床医学进展》
2023年第6期9223-9229,共7页
Advances in Clinical Medicine
