主动脉夹层原发破口位置与ABO血型的相关性分析

Analysis of the Correlation between the Location of Primary Rupture of Aortic Dissection and ABO Blood Group

目的:研究ABO血型对主动脉夹层(aortic dissection, AD)原发破口的位置影响,为AD的预防及发病机制的研究提供新的思考。方法:采用回顾性队列研究方法,收集2019年4月至2022年10月在海南医学院第二附属医院就诊AD患者,根据纳入排除标准收集O型血组83例、非O型血组92例。采用多因素logistics回归分析分析纳入研究的因素对AD原发破口位置的影响。结果:多因素logistics回归分型显示,BMI OR = 1.103 (1.109~1.194, p = 0.016)与AD原发破口位于升主动脉显著相关;O型血OR = 0.259 (95% CI 0.116~0.577, p = 0.001)、吸烟史OR = 2.878 (1.360~6.090, p = 0.006)与AD原发破口位于主动脉弓显著相关。结论:非O型血是AD原发破口位于主动脉弓的独立危险因素,而O型血是AD原发破口位于其他位置的独立危险因素,因而我们认为ABO血型通过影响AD原发破口位置,参与AD的发生发展。

Objective: The study of the influence of ABO blood group on the position of primary rupture of aortic dissection (AD) provides new thinking for the prevention and pathogenesis of AD. Methods: A ret-rospective cohort study was conducted to collect AD patients admitted to the Second Affiliated Hos-pital of Hainan Medical University from April 2019 to October 2022. According to the inclusion and exclusion criteria, 83 cases in the O group and 92 cases in the non-0 group were collected. Mul-ti-factor logistics regression analysis was used to analyze the influence of the factors included in the study on the location of the primary AD rupture. Results: Multi-factor logistics regression classifica-tion showed that BMI OR = 1.103 (1.109~1.194, p = 0.016) was significantly correlated with the lo-cation of primary AD rupture in the ascending aorta. Blood type O OR = 0.259 (95% CI 0.116~0.577, p = 0.001), smoking history OR = 2.878 (1.36~6.090, p = 0.006) were significantly correlated with the location of primary AD rupture in aortic arch. Conclusions: Non-O blood group is an independent risk factor for primary AD rupture located in the aortic arch, while O blood group is an independent risk factor for primary AD rupture located in other locations. Therefore, we believe that ABO blood group is involved in the occurrence and development of AD by affecting the location of primary AD rupture.