妊娠期高血压疾病的预防研究进展

Research Progress on Prevention of Hypertensive Disorders of Pregnancy

妊娠期高血压疾病(Hypertensive Disorders of Pregnancy, HDP)是妊娠与血压升高并存的一组疾病,该组疾病包括妊娠期高血压,子痫前期,子痫,以及慢性高血压并发子痫前期和妊娠合并慢性高血压。HDP发生率5.2%~8.2%,是孕产妇和围产儿病死率升高的主要原因。子痫前期是HDP中最常见的,由于现阶段子痫前期的治疗方式有限,且危害较重,子痫前期的预防显得非常重要,并且近年来对预防这种疾病的兴趣以及对其病理生理学的更好理解导致了预防此疾病制剂的研究不断增加,本文综述了该疾病的主要病理生理学机制,并总结目前正在被用于子痫前期的预防或者有预防子痫前期潜力的药物及方法。

Hypertensive Disorders of Pregnancy (HDP) is a group of diseases in which pregnancy and elevated blood pressure coexist. This group of diseases includes gestational hypertension, preeclampsia, ec-lampsia, and chronic hypertension complicated with preeclampsia and pregnancy with chronic hy-pertension. The incidence of HDP is 5.2%~8.2%, which is the main cause of maternal and perinatal mortality. Preeclampsia is the most common type of HDP. Due to the limited treatment of preeclampsia at this stage and the serious harm, the prevention of preeclampsia is very important. In recent years, the interest in preventing this disease and the better understanding of its patho-physiology have led to the prevention of this disease. The research on preparations is increasing. This article reviews the main pathophysiological mechanisms of the disease, and summarizes the drugs and methods that are currently being used for the prevention of preeclampsia or have the potential to prevent preeclampsia.