绝经后铁代谢的变化对骨密度的影响

The Effect on Bone Mineral Density of Iron Metabolism Changes in Postmenopausal Women

骨质疏松症(OP)由于其在老年人中的高发病率和高致骨折率,长期以来一直受到广泛的关注。随着世界各国人口老龄化的到来及加剧,骨质疏松症的患病率逐年上升,绝经后妇女由于体内雌激素的减少,对破骨细胞的分化和骨吸收的抑制作用降低,加速了骨量的流失,易导致绝经后骨质疏松症。体内铁含量水平及铁代谢与骨代谢有着密切的联系,不管是体内铁增多还是铁缺乏都会影响破骨细胞和成骨细胞的分化和活性,从而促进骨质流失,但对于体内铁代谢是如何影响骨密度及骨代谢,本综述简要阐述了体内铁含量及铁代谢对骨密度及骨代谢影响的有关机制,从而为铁相关性绝经后骨质疏松症的研究、预防及治疗提供新的临床思路。

Osteoporosis (OP) has been widely concerned for a long time because of its high incidence and frac-ture rate in the elderly. With the arrival and aggravation of the aging of the world’s population, the prevalence of osteoporosis is increasing year by year. Because of the reduction of estrogen in post-menopausal women, the inhibition of osteoclast differentiation and bone resorption is reduced, which accelerates the loss of bone mass and easily leads to postmenopausal osteoporosis. The level of iron content and iron metabolism in the body are closely related to bone metabolism. Both iron increase and iron deficiency in the body will affect the differentiation and activity of osteoclasts and osteoblasts, thus promoting bone loss. However, how iron metabolism in the body affects bone den-sity and bone metabolism is briefly described in this review, It provides a new clinical idea for the research, prevention and treatment of iron related postmenopausal osteoporosis.