肝脏切除后肝脏再生的研究进展

Research Progress in Liver Regeneration after Liver Resection

在肝胆外科领域中,对肝脏的切除是治疗肝脏良恶性疾病的有效手段。过大范围的肝脏切除也增加了肝衰竭的风险,近些年来,大量体内体外实验研究了促进肝脏术后再生以预防小肝综合征和肝衰竭发生的方法,但与此同时,有研究结果表明,肝脏切除术后肝脏的再生也会促进肿瘤的生长从而激活隐匿病灶的复发,因此,如何权衡肝脏术后再生以及抑制肿瘤复发两者之间的关系,成为目前肝胆外科一个亟待解决的问题。本文就从肝再生的典型模型、肝脏再生的机制、肝再生与肿瘤复发的关系三个方面对肝再生的研究进展做一综述。

In the field of hepatobiliary surgery, liver resection is an effective method for treating benign and malignant liver diseases. Excessive liver resection also increases the risk of liver failure. In recent years, a large number of in vitro and in vivo experiments have studied methods to promote liver regeneration after surgery to prevent small liver syndrome and liver failure. However, at the same time, research results have shown that liver regeneration after liver resection also promotes tumor growth and activates the recurrence of hidden lesions. Therefore, How to balance the relationship between postoperative liver regeneration and tumor recurrence inhibition has become an urgent problem to be solved in liver and gallbladder surgery. This article reviews the research progress of liver regeneration from three aspects: typical models of liver regeneration, mechanisms of liver re-generation, and the relationship between liver regeneration and tumor recurrence.