肠道微生物与动脉粥样硬化性脑卒中的研究进展

Advances in the Study of Gut Microbes and Atherosclerotic Stroke

肠道微生物群是人体内最大的微生物库,在神经发育和衰老以及缺血性脑卒中等脑部疾病中发挥着重要作用。肠道细菌产生神经活性化合物可以调节神经元功能,从而影响缺血性脑卒中后的行为。此外,肠道微生物会影响宿主代谢和免疫状态,进而影响缺血性大脑的神经元网络。在这里,我们讨论了动物和人类研究在缺血性脑卒中中沿肠–脑轴双向交流的结果。

The gut microbiota is the largest reservoir of microorganisms in the body and plays an important role in neurodevelopment and aging as well as in brain diseases such as ischemic stroke. The pro-duction of neuroactive compounds by gut bacteria can modulate neuronal function and thus influ-ence behavior after ischemic stroke. In addition, gut microbes affect host metabolism and immune status, which in turn influence neuronal networks in the ischemic brain. Here, we discuss the re-sults of animal and human studies on bidirectional communication along the gut-brain axis in is-chemic stroke.