摘要
银屑病是一种常见的慢性炎症性皮肤病。根据流行病学调查显示,其患病率呈上升趋势。白细胞介素23 (IL-23)/辅助性T细胞17 (Th17)通路在银屑病发病中起重要作用,目前被广泛用于银屑病的研究。大量的分子生物学实验表明,中药单体或有效成分、中药复方可通过调节IL-23/Th17通路,影响相关细胞因子和转录因子,以达到减轻银屑病炎症反应、恢复正常机体免疫功能。综述近年来中药单体及中药复方通过调节IL-23/Th17通路治疗银屑病的相关研究成果,以期为中药研发及临床防治提供新的思路。
Psoriasis is a common chronic inflammatory skin disease. According to the epidemiological survey, its prevalence is on the rise. The interleukin-23 (IL-23)/Helper T cell 17 (Th17) pathway plays an important role in the pathogenesis of psoriasis and is widely used in the study of psoriasis. A large number of molecular biology experiments have shown that TCM monomeric or active components and TCM compounds can affect related cytokines and transcription factors by regulating IL-23/Th17 pathway, so as to reduce inflammation in psoriasis and restore normal immune func-tion. In order to provide new ideas for TCM research and development, clinical prevention and treatment, the recent research results of TCM monomer and TCM compound in the treatment of psoriasis by regulating IL-23/Th17 pathway were reviewed.
出处
《临床医学进展》
2023年第7期10943-10948,共6页
Advances in Clinical Medicine
