MAGOH及MAGOHB在恶性肿瘤中的研究进展

Advances in the Study of MAGOH and MAGOHB in Malignant Tumors

MAGOH和MAGOHB是外显子连接复合物(EJC)的关键组成成分,它参与mRNA的剪接、翻译和定位。MAGOHB是MAGOH同一家族的密切相关成员,其是进化保守的重复MAGOH基因。这两种MAGOH基因位于人类不同的染色体上(MAGOH:第1条;MAGOHB:第12条),两者均包含具有保守长度和结构的五个外显子。由于染色体1p经常丢失使得MAGOH缺失成为了一种普遍的遗传事件,在MAGOH缺失时,MAGOHB会替代MAGOH在EJC中起作用。研究表明,MAGOHB基因与多种癌症的发生发展有关。因此,该文就MAGOHB在恶性肿瘤中的最新进展进行了综述。

MAGOH and MAGOHB are key components of the exon junction complex (EJC), which is involved in the splicing, translation and localization of mRNA. magohB is a closely related member of the same family of MAGOH, which are evolutionarily conserved repetitive MAGOH genes. The two MAGOH genes are located on different human chromosomes (MAGOH: chromosome 1;MAGOHB: chromo-some 12) and both contain five exons with conserved length and structure. The frequent loss of chromosome 1p makes MAGOH deletion a common genetic event, and in the absence of MAGOH, MAGOHB acts in place of MAGOH in EJC. Studies have shown that the MAGOHB gene is associated with the development of several cancers. Therefore, this article provides a review of the recent pro-gress of MAGOHB in malignancies.