心外膜脂肪组织及其与房颤关系的研究进展

Research Progress on Epicardial Adipose Tissue and Its Relationship with Atrial Fibrillation

心外膜脂肪组织(EAT)是位于心肌与心包脏层之间的代谢活跃的脂肪库。相比于人体其他内脏脂肪库,EAT不仅具有产热、机械保护的共同特性,还兼有独特分泌功能。研究证实,EAT与房颤的发生及射频消融术后复发相关。EAT导致房颤的机制尚未完全阐明,可能的机制涉及心肌纤维化、脂肪细胞浸润、神经调节失衡等。近年来,EAT受到高度关注,或许会成为预测房颤发生及房颤射频术后复发的一项危险因素。Epicardial adipose tissue (EAT) is an active metabolic fat reservoir located between the myocardi-um and the visceral layer of the pericardium. Compared to other visceral fat reservoirs in the hu-man body, EAT not only has common characteristics of heat production and mechanical protection, but also has unique secretion functions. Research has confirmed that EAT is associated with the oc-currence of atrial fibrillation and recurrence after radiofrequency ablation. The mechanism of EAT leading to atrial fibrillation has not been fully clarified, and the possible mechanism involves myo-cardial fibrosis, adipocyte infiltration, neuromodulation imbalance, etc. In recent years, EAT has received high attention and may become a risk factor for predicting the occurrence and recurrence of atrial fibrillation after radiofrequency surgery.