结直肠息肉与2型糖尿病的危险因素及相关性分析

Risk Factors and Correlation Analysis of Colorectal Polyps and Type 2 Diabetes Mellitus

结直肠癌(colorectal cancer, CRC)在世界范围内十分常见,且恶性程度较高。结肠息肉与结肠癌有紧密关系。结直肠息肉是消化科常见疾病。结肠息肉是结肠黏膜面上隆起的赘生物统称,按病理类型分为非腺瘤性息肉和腺瘤性息肉,后者临床上更为常见,基于“腺瘤–不典型增生–癌”的癌变模式,结直肠腺瘤被认为是结直肠癌最重要的癌前病变。因此探索结直肠息肉相关的危险因素,对于预防CRC至关重要。2型糖尿病(Type 2 diabetes, T2DM)作为临床常见的慢性代谢性疾病,发病率逐年升高,严重影响人类健康,它不仅会引起大血管、微血管、神经系统病变,还可以增加肿瘤的发生风险。因此尽早筛查,及时预防可在一定程度上降低结直肠癌的发生。

Colorectal Cancer (CRC) is very common in the world and has a high malignant degree. Colon polyps are closely related to colon cancer. Colorectal polyp is a common disease in gastroenterology. Colon polyps are the general name of the growths raised on the mucosal surface of the colon, which can be divided into non-adenomatous polyps and adenomatous polyps according to pathological types. The latter is more common clinically. Based on the canceration pattern of “adenoma-atypical hyper-plasia-carcinoma”, colorectal adenoma is considered to be the most important precancerous lesion of colorectal cancer. Therefore, it is important to explore the risk factors related to colorectal polyps for the prevention of CRC. Type 2 diabetes (T2DM), as a common chronic metabolic disease in clini-cal practice, has an increasing incidence year by year, which seriously affects human health. It can not only cause major vascular, microvascular and nervous system lesions, but also increase the risk of tumor. Therefore, early screening and timely prevention can reduce the occurrence of colorectal cancer to a certain extent.