氨甲环酸在围手术期脊柱手术的应用进展

Application Progress of Tranexamic Acid in Perioperative Spinal Surgery

骨科脊柱大手术中常伴随大量失血的风险,如何减少患者围手术期出血、减少或避免输入异体血制品方法受许多骨科医生关注。近年来,氨甲环酸作为一种围手术期止血药及减少输血药物已得广泛关注,国内外许多学者报道氨甲环酸可以有效减少围手术期失血和输血,从而达到节约患者费用,改善患者预后。但其手术范围、最佳剂量、给药途径、不良反应等至今未能完全明确,需要进一步研究。

The risk of massive blood loss in major orthopaedic spine surgery is often associated with how to reduce perioperative bleeding, and reduce or avoid the introduction of allogeneic blood products methods for many orthopedic surgeons. In recent years, tranexamic acid has been widely concerned as a perioperative hemostatic and blood transfusion drug. Many scholars at home and abroad have reported that tranexamic acid can effectively reduce perioperative blood loss and blood transfusion, so as to economize and improve the prognosis of the patients. However, the range of operation, op-timal dosage, route of administration and adverse reactions are not completely clear up to now and need further study.