褪黑素在脓毒症辅助治疗中的研究进展

Research Progress of Melatonin in Adjuvant Therapy of Sepsis

脓毒症是一种以高发病率、高病死率为主要特征的临床综合征,可引起全身炎症反应及多器官功能衰竭,严重威胁人们生命安全。褪黑素是一种多功能吲哚激素,具有多种生物学功能,褪黑素对脓毒症的治疗效果与其抗炎、抗氧化应激等功能密切相关,值得我们更加深入地研究褪黑素在脓毒症治疗中的辅助治疗效果。本文主要从褪黑素的生物学功能、褪黑素在脓毒症治疗中的应用以及褪黑素的安全性和有效性等方面进行综述。

Sepsis is a clinical syndrome characterized by high morbidity and mortality, which can cause sys-temic inflammation and multiple organ failure, and seriously threaten people’s life safety. Melato-nin is a multifunctional indole hormone with a variety of biological functions. The therapeutic effect of melatonin on sepsis is closely related to its anti-inflammatory and antioxidant stress functions, so it is worth further studying the adjuvant therapeutic effect of melatonin in the treatment of sepsis. This article mainly reviews the biological function of melatonin, the application of melatonin in the treatment of sepsis, and the safety and effectiveness of melatonin.