二肽基肽酶4抑制剂对老年2型糖尿病合并动脉粥样硬化调节作用的研究进展

Research Progress of Dipeptidyl Eptidase 4 Inhibitors in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Atherosclerosis

二肽基肽酶4抑制剂近年来已在临床上广泛应用。越来越多的证据表明二肽基肽酶4抑制剂在2型糖尿病治疗中除了降血糖作用外,还具有对心血管系统的保护调节作用,临床中特别是对老年2型糖尿病合并动脉粥样硬化患者的治疗有一定的作用,但目前对二肽基肽酶4抑制剂在心血管方面的调节作用研究方面争议较大,本文就二肽基肽酶4抑制剂对动脉粥样硬化调节作用的研究进展进行总结和论述。

Dipeptidyl peptidase 4 inhibitors have been widely used in clinical practice in recent years. More and more evidence has shown that dipeptidyl peptidase 4 inhibitors have a protective regulatory effect on the cardiovascular system in addition to hypoglycemic effect in the treatment of type 2 di-abetes mellitus, especially in the treatment of elderly patients with type 2 diabetes mellitus com-plicated with atherosclerosis. However, the research on the regulatory effect of dipeptidyl peptidase 4 inhibitors on cardiovascular aspects is controversial. In this paper, the research progress of di-peptidyl peptidase 4 inhibitors against atherosclerosis is summarized and discussed.