逆转结肠癌奥沙利铂耐药的研究进展

Research Progress on Reversing Oxaliplatin Resistance in Colon Cancer

结直肠癌是在全球发病率居第三位,死亡率居第二位的恶性肿瘤,严重威胁人类的身体健康。化疗是结肠癌常见的治疗方法,化疗耐药是影响结肠癌患者疗效和预后的主要因素。奥沙利铂作为结肠癌术后辅助及晚期一线治疗的基石药物,为广大结肠癌患者带来生存获益,但其耐药也是不可避免的。这也是结肠癌患者临床化疗失败并导致肿瘤复发和转移的主要原因之一。因此,探究结肠癌奥沙利铂耐药的分子机制并逆转其耐药,对提高结肠癌患者治疗疗效、改善患者预后具有重大意义。本文将较为详尽地阐明近年来关于逆转结肠癌奥沙利铂耐药的最新研究进展,以为临床进一步治疗及研究提供参佐。

Colorectal cancer is a malignant tumor with the third highest incidence and the second highest mortality in the world, which is a serious threat to the health of patients. Chemotherapy is a com-mon treatment for colon cancer, and chemotherapy resistance is the main factor affecting the effi-cacy and prognosis of patients with colon cancer. As a cornerstone drug of postoperative adjuvant and advanced line therapy for colon cancer, oxaliplatin brings survival benefits for the majority of colon cancer patients, but its drug resistance is also inevitable. This is also the main reason for the failure of clinical chemotherapy in patients with colon cancer and leading to tumor recurrence and metastasis. Therefore, to explore the molecular mechanism of oxaliplatin resistance in colon cancer and reverse its drug resistance is of great significance to improve the therapeutic efficacy and prognosis of patients with colon cancer. This article will clarify in detail the latest research progress on reversing oxaliplatin resistance in colon cancer in recent years, so as to provide reference for further clinical treatment and research.