中性粒细胞/淋巴细胞比值与痛风患者肾功能损伤的相关性分析

Correlation between Neutrophil to Lymphocyte Ratio and Renal Function Damage in Gout Patients

目的:分析中性粒细胞/淋巴细胞的比值(NLR)与痛风患者肾功能损伤的相关性。方法:收集2022年1月至2022年12月在青岛大学附属烟台毓璜顶医院风湿科诊治的484例痛风患者的临床资料。根据e-GFR将患者分为肾功能损伤组(105例)和肾功能正常组(379例),分析两组患者的一般临床资料、血常规、生化及炎症指标的差异,并采用多因素Logistic回归分析痛风患者肾功能损伤的危险因素。结果:肾功能损伤组患者的女性占比、年龄、病程、合并慢性疾病(高血压病、糖尿病)比例、NLR、红细胞分布宽度、肌酐、胱抑素C、C反应蛋白明显高于肾功能正常组,而红细胞、血红蛋白、淋巴细胞、高密度脂蛋白胆固醇明显低于肾功能正常组,差异具有统计学意义(P < 0.05)。多因素Logistic回归显示年龄、NLR及肌酐是痛风患者发生肾功能损伤的独立危险因素(P < 0.05)。结论:痛风患者肾功能损伤受多个因素影响,NLR值升高是肾功能损伤的独立危险因素。

Objective: To investigate the correlation between neutrophil to lymphocyte ratio and renal function damage in gout patients. Methods: A total of 484 gout patients treated in the Department of Rheu-matology, Yantai Yuhuangding Hospital affiliated to Qingdao University from January 2022 to De-cember 2022 were collected and divided into renal function damage group (105 cases) and normal renal function grout (379 cases) according to e-GFR. The differences in general clinical data, blood routine, biochemical and inflammatory indicators between the two groups were analyzed, and mul-tivariate logistic regression was used to analyze the risk factors of renal function damage in gout patients. Results: The proportion of females, age, course of disease, proportion of chronic diseases (hypertension, diabetes), NLR, red blood cell distribution width, creatinine, cystatin C and C-reactive protein in renal function damage group were significantly higher than those in normal renal func-tion group, while the red blood cell, hemoglobin, lymphocyte and high-density lipoprotein choles-terol were significantly lower than those in normal renal function group, the difference was statisti-cally significant (P < 0.05). Multivariate analysis showed that age, NLR and creatinine were the in-dependent risk factors for renal function damage in gout patients (P < 0.05). Conclusion: Renal function damage in gout patients is influenced by multiple factors, and the increase of NLR is an in-dependent risk factor for renal function damage.