抗血管生成治疗中晚期宫颈癌的研究进展

Advances in Anti-Angiogenesis Therapy for Middle and Advanced Cervical Cancer

宫颈癌在女性恶性肿瘤中较为常见,发病率和死亡率均较高。早期宫颈癌可通过手术根治,而中晚期宫颈癌通过手术常无法达到根治目的,主要采用放化同步治疗。然而,宫颈癌组织中存在异常的血管生成,往往造成肿瘤内部缺血缺氧,使放化疗不能得到满意的效果,为肿瘤的生长和转移提供了有利的条件。因此,通过抗血管生成来抑制恶性肿瘤的生长、增殖和转移成为宫颈癌治疗的新方向。

Cervical cancer is a common malignancy in women with high morbidity and mortality. Early cervical cancer can be treated by radical surgery, while middle and advanced cervical cancer often cannot be treated by radical surgery, the main treatment is radiochemical simultaneous therapy. However, abnormal angiogenesis in cervical cancer tissues often leads to internal tumor ischemia and hypox-ia, which makes chemoradiotherapy unable to achieve satisfactory results and provides favorable conditions for tumor growth and metastasis. Therefore, anti-angiogenesis to inhibit the growth, pro-liferation and metastasis of malignant tumors has become a new direction of cervical cancer treat-ment.