丁型肝炎流行病学特征及临床表现研究进展

Research Progress on Epidemiological Characteristics and Clinical Manifestations of Hepatitis D

丁型肝炎是丁型肝炎病毒(hepatitis D virus HDV)感染引起的肝脏疾病。HDV是一种有缺陷的小RNA病毒,其复制依赖于乙型肝炎病毒(hepatitis B virus HBV)辅助,以乙型肝炎病毒表面抗原(HBsAg)作为其外膜。HBV/HDV重叠感染可加速肝脏疾病进展,导致肝硬化、肝功能失代偿、肝细胞癌(hepatocellular carcinoma HCC)以及肝病相关死亡的风险显著增加。目前我国丁型肝炎流行病学筛查资料尚不完善,我国作为乙肝患病率较高的国家,而丁肝患病率严重被低估,本文的目的是阐述丁型肝炎流行病学现状包括起源、基因型、易感人群及临床表现,阐明丁型肝炎流行病学特点及临床症状特点,并提出未来重点关注人群及临床表现的方向。

Hepatitis D is a liver disease caused by hepatitis D virus (HDV) infection. HDV is a defective small RNA virus. Its replication depends on the assistance of hepatitis B virus (HBV), with hepatitis B vi-rus surface antigen (HBsAg) as its outer membrane. HBV/HDV superinfection can accelerate the progression of liver disease, leading to a significant increase in the risk of cirrhosis, decompensation of liver function, hepatocellular carcinoma (HCC) and liver disease related death. At present, the epidemiological screening data of hepatitis D in China are not perfect. As a country with a high prevalence rate of hepatitis B, the prevalence rate of hepatitis D is seriously underestimated. The purpose of this paper is to describe the current epidemiological situation of hepatitis D, including its origin, genotype, susceptible population and clinical manifestations, to clarify the epidemiologi-cal characteristics and clinical symptoms of hepatitis D, and to propose the direction of focusing on the population and clinical manifestations in the future.