高血压药物相关基因位点多态性分布现况

Distribution of Polymorphisms of Drug-Related Gene Loci in Hypertension

高血压是心脑血管病的首要危险因素。服用降压药物是目前控制高血压的最主要的措施,然而个体间药物疗效差异性大。药物基因组学发现个体间相关基因位点分布存在多态性。现阶段在多个地区已开展降压药物相关代谢基因位点多态性检测并指导临床用药,其疗效优于传统经验用药。因此,本文旨在对该领域的相关进展进行综述,为高血压药物治疗提供依据。

Hypertension is the primary risk factor for cardiovascular and cerebrovascular diseases. At present, taking antihypertensive drugs is the most important measure to control hypertension, but the drug effect varies greatly among individuals. Pharmacogenomics found polymorphism in the distribution of relevant loci among individuals. At present, polymorphism detection of metabolic gene loci re-lated to antihypertensive drugs has been carried out in many areas to guide clinical drug use, and its efficacy is better than traditional empirical drugs. Therefore, this article aims to review the rel-evant progress in this field and provide basis for the drug treatment of hypertension.