基于LPS/TLR4/NF-κB信号通路探讨中药干预糖尿病慢性炎症状态研究进展

Based on the Results of LPS/TLR4/NF-κB Signaling Pathways in TCM Interventions for the Chronic Inflammatory State of Diabetes

随着高脂饮食、运动量减少等不良生活习惯的形成,糖尿病患者数量与日俱增,已成为全球严重的公共卫生问题,为缓解社会经济负担和医疗压力,探析糖尿病的有效治疗手段和抑制恶化一直是目前的首要主攻方向。近年来研究显示,肠道菌群失调与糖尿病的发生发展密切相关,其通过诱发体内代谢性内毒素血症、胆汁酸代谢紊乱和短链脂肪酸(SCFA)生成减少等机制导致糖尿病的病理过程发生,其中尤以LPS/TLR4/NF-κB信号通路与糖尿病的慢性炎症状态和胰岛素抵抗(IR)的发生关联密切。中医药一直被运用于糖尿病的治疗,临床及动物实验疗效显著,且不良反应小,目前关于中医药的活性成分及中医药复方通过抑制LPS/TLR4/NF-κB信号通路中的炎症因子分泌,阻断糖尿病持续慢性炎症损伤,调节IR,改善糖尿病症状的研究十分广泛,以此为切入点通过对近年来中医药的活性成分及中医药复方抑制LPS/TLR4/NF-κB信号通路治疗糖尿病慢性炎症状态的研究进展做一简要综述,以期为糖尿病的防治药物及治疗方法探究提供有力证据支持。

With the formation of poor lifestyle habits such as high-fat diet and reduced exercise, the number of diabetes patients is increasing day by day and has become a serious public health problem world-wide. To alleviate the social and economic burden and medical pressure, exploring effective treat-ments for diabetes and inhibiting its deterioration has been the primary main focus at present. Re-cent studies have shown that dysbiosis of intestinal flora is closely related to the development of diabetes, which leads to the pathological process of diabetes by inducing metabolic endotoxemia, disturbance of bile acid metabolism and reduction of short-chain fatty acid (SCFA) production in vi-vo, among which the LPS/TLR4/NF-κB signaling pathway is closely associated with the chronic in-flammatory state and the development of insulin resistance (IR) in diabetes. Chinese medicine has been used in the treatment of diabetes mellitus, with significant efficacy and low adverse effects in clinical and animal experiments. Currently, there is extensive research on the active ingredients of Chinese medicine and Chinese medicine compound to block the continuous chronic inflammatory damage in diabetes mellitus, regulate IR and improve the symptoms of diabetes mellitus by inhib-iting the secretion of inflammatory factors in LPS/TLR4/NF-κB signaling pathway. This is the start-ing point for a brief review of the recent research progress on the active ingredients of TCM and TCM compound to inhibit LPS/TLR4/NF-κB signaling pathway in the treatment of chronic inflammatory state of diabetes mellitus, in order to provide strong evidence to support the investigation of drugs and treatment methods for diabetes mellitus.