线粒体功能相关检测方法的研究进展

Research Progress on Detection Methods Related to Mitochondrial Function

线粒体(mitochondria)是真核细胞重要的细胞器,是细胞的“能量工厂”。线粒体功能障碍主要表现为线粒体形态、结构和功能异常,包括:线粒体异常体积、数量的增加或减少、线粒体膜电位异常,线粒体DNA损伤等。研究发现,这些线粒体结构、功能的变化与多种疾病的发生发展密切相关。而随着生物检测技术的发展,对线粒体结构和功能的检测方法也不断更新,现就线粒体结构和功能相关的检测方法及其研究进展作一综述。

Mitochondria are important organelles of eukaryotic cells and the “energy factory” of cells. Mito-chondrial dysfunction mainly manifests as abnormal mitochondrial morphology, structure, and function, including: abnormal volume, increase or decrease of mitochondrial number, abnormal mitochondrial membrane potential, mitochondrial DNA damage, etc. Studies have found that these changes in mitochondrial structure and function are closely related to the occurrence and devel-opment of various diseases. With the development of bioassay technology, the detection methods of mitochondrial structure and function are constantly updated, and the detection methods and re-search progress related to mitochondrial structure and function are reviewed here.