摘要
复发性流产(RSA)是女性不孕症中的一种复杂类型,其病因复杂,约50%的RSA患者病因不明,由于蜕膜化异常所致的反复流产成为学者关注的焦点。近年来长链非编码RNA (lncRNA)的研究快速兴起,由于其作用机制多样,且生物学功能更加强大,已成为表观遗传学领域一个新的研究热点。越来越多的研究报道lncRNA可通过调控靶基因的表达,从而参与女性生殖疾病的发生与发展。其中lncRNA与流产相关疾病机制的关系也逐渐受到学者的重视。本文就lncRNA与RSA之间的关系进行综述。
Recurrent abortion (RSA) is a complex type of female infertility with a complex etiology, about 50% of RSA patients have unknown causes. Repeated abortions due to abnormal decidualization have become the focus of scholars. In recent years, the research of long non-coding RNA (lncRNA) has risen rapidly. It has become a new research hotspot in the field of epigenetics due to its diverse ac-tion mechanisms and more powerful biological functions. A growing number of studies have re-ported that lncRNA can participate in the occurrence and development of female reproductive dis-eases by regulating the expression of target genes. Among them, the relationship between lncRNA and abortion-related disease mechanism has been gradually valued by scholars. This review sum-marizes the relationship between lncRNA and RSA.
出处
《临床医学进展》
2023年第9期15061-15065,共5页
Advances in Clinical Medicine
