环氧合酶与前列腺癌关系研究进展

Research Progress on the Relationship between Cox Pathway and Prostate Cancer

前列腺癌是严重威胁男性健康的恶性肿瘤之一,目前其治疗效果欠佳。近些年来,相关研究发现环氧合酶通路上的物质与前列腺癌的发生、发展和转移密切相关。尤其是环氧合酶-2和前列腺素E2在前列腺癌中进展中发挥举足轻重的作用。进一步研究COX通路上与前列腺癌的关系,对前列腺癌防治有重要意义。本文从环氧合酶通路物质对前列腺癌的影响,及相关抑制剂的作用等关系做综述。

Prostate cancer is one of the malignant tumors that threaten the health of men seriously. In recent years, it has been found that Cox pathway is closely related to the occurrence, development and metastasis of prostate cancer. In particular, Cox-2 and PGE2 play a pivotal role in the progression of prostate cancer. Further study on the relationship between Cox pathway and prostate cancer is of great significance for the prevention and treatment of prostate cancer. This article reviews the ef-fect of Cox pathway on prostate cancer and the role of related inhibitors.