类风湿性关节炎疼痛机制的研究进展

Research Progress on the Mechanisms of Pain in Rheumatoid Arthritis

类风湿性关节炎是一种可引起机体关节疼痛、肿胀、畸形甚至器官损害的自身免疫性疾病。全球发病普遍,中国发病率为0.42%,全球为0.27%。除关节问题外,该疾病还会导致患者生活质量下降,严重者甚至会给社会带来沉重的经济负担。本文着眼于类风湿性关节炎引起疼痛的潜在机制,从细胞因子、信号转导途径以及微小核糖核酸三方面阐述目前类风湿性关节炎疼痛机制的研究进展,并适当结合说明此疾病的临床诊疗方法,对类风湿性关节炎未来的研究方向做出了相应的展望。

Rheumatoid arthritis (RA) is an autoimmune disease that can cause joint pain, swelling, deformity and even organ damage. It is prevalent globally, with an incidence of 0.27% worldwide and 0.42% in China. In addition to joint problems, the disease can also lead to a decline in the quality of life of patients, and even bring a heavy economic burden to society in severe cases. The primary objective of this paper is to delve into the mechanisms responsible for the pain induced by RA. It aims to elu-cidate the current advancements in research concerning cytokines, signaling pathways, and mi-croRNAs. The article appropriately integrates clinical diagnosis and treatment methods for this condition and provides a perspective on future research directions in the field of rheumatoid ar-thritis.