PCSK9抑制剂在颈动脉狭窄中的应用进展

Application of PCSK9 Inhibitor in Carotid Stenosis

颈动脉狭窄(Carotid Artery Stenosis, CAS)是急性缺血性脑卒中(Ischemic Stroke, IS)的原因之一,其主要原因是动脉粥样硬化(Atherosclerosis, AS)。低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol, LDL-C)异常是导致AS的重要危险因素。近年的研究发现人前蛋白转化酶枯草溶菌素kexin 9型(proprotein convertase subtilisin/kexin type 9, PCSK9)在动脉粥样硬化斑块形成扮演者重要角色。PCSK9抑制剂已被证实可以改善心血管疾病的预后,目前广泛应用于心血管疾病,但是缺乏在CAS中应用的相关报道。本文对PCSK9抑制剂在CAS中的应用做一综述。

Carotid Artery Stenosis (CAS) is one of the causes of acute ischemic stroke (IS), and its main cause is atherosclerosis (AS). The abnormality of low density lipoprotein cholesterol (LDL-C) is an important risk factor leading to AS. Recent studies have found that human prothrombin invertase kexin 9 (PCSK9) plays an important role in atherosclerotic plaque formation. PCSK9 inhibitors have been proved to improve the prognosis of cardiovascular diseases. They are widely used in cardiovascular diseases, but there is no relevant report on the application of PCSK9 inhibitors in CAS. This article reviews the application of PCSK9 inhibitors in CAS.