晚期糖基化终产物在糖尿病肾病中的致病作用及防治策略

Pathogenic Role and Preventive Strategy of Advanced Glycation End Products in Diabetic Kidney Disease

糖尿病肾病(DKD)是糖尿病主要的微血管并发症之一,是导致糖尿病患者发病和死亡的主要原因,也是导致终末期肾病(ESRD)的主要原因,严重危害人类健康。DKD的发生与持续高血糖密切相关,体内高糖环境下积聚的晚期糖基化终产物(AGEs)是DKD的主要致病因素。AGEs在体内的持续蓄积会引起一系列氧化应激等级联反应及激活多条信号通路,最终导致肾脏损伤。AGEs在DKD发生发展过程中的作用是近年来的研究热点。本文就AGEs的来源、生化特性、病理生理机制及相关防治策略作如下综述。

Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes mellitus, which is the main cause of morbidity and mortality in diabetes mellitus patients, and also the main cause of end-stage renal disease (ESRD), which is a serious hazard to human health. DKD is closely related to persistent hyperglycemia, and the accumulation of advanced glycation end products (AGEs) in the body under the environment of high glucose is a major pathogenic factor in DKD. The accumulation of AGEs in the body causes a series of oxidative stress cascade reactions and activation of multiple signalling pathways, which ultimately leads to kidney injury. The role of AGEs in the de-velopment of DKD has been a hot topic of research in recent years. In this paper, we review the sources, biochemical properties, pathophysiological mechanisms and prevention strategies of AGEs.