长链非编码RNA ST8SIA6-AS1在恶性肿瘤中的研究进展

Research Progress of LncRNA ST8SIA6-AS1 in Malignant Tumors

长链非编码RNA (long non-coding RNAs, LncRNA)是一种长度超过200个核苷酸的非编码RNA,尽管LncRNA占所有转录物的不到2%,但其在调节基因表达水平发挥重要作用,广泛参与人类疾病进展。很少有LncRNA被发现对癌细胞存活至关重要,尤其是对多种癌症类型至关重要的LncRNA。长链非编码RNA ST8SIA6-AS1被发现在多种肿瘤中处于失调状态,如垂体腺瘤、肝细胞癌、肺癌、乳腺癌及结直肠癌等。本综述结合近期文献,总结ST8SIA6-AS1参与肿瘤的发生发展作用与分子机制,为进一步研究提供参考。

Long non-coding RNAs are non-coding RNAs more than 200 nucleotides in length. Although LncRNAs account for less than 2% of all transcripts, they play an important role in regulating gene expression levels and are widely involved in the progression of human diseases. Few LncRNAs have been found to be critical for cancer cell survival, especially those critical for multiple cancer types. LncRNA ST8SIA6-AS1 has been found to be dysregulated in a variety of tumors, such as pituitary adenoma, hepatocellular carcinoma, lung cancer, breast cancer, and colorectal cancer. In this re-view, we summarize the role and molecular mechanisms of ST8SIA6-AS1 involved in tumor devel-opment, which provides a reference for further studies.