LncRNA在宫颈病变发生发展中的作用及机制研究进展

Research Progress on the Role and Mechanism of LncRNA in the Occurrence and Development of Cervical Lesions

宫颈癌是女性生殖系统中最常见的恶性肿瘤之一,主要是由高危型人乳头瘤病毒(human papillo-mavirus, HPV)感染引起,从高危型HPV感染到发展为宫颈病变是一个极其复杂的多阶段、多基因调控异常的过程。长链非编码RNA (long non-coding RNA, LncRNA)是无编码蛋白质功能的RNA (>200个核苷酸),但它在转录、转录后的表观遗传水平起作用,与人类癌症的发生、侵袭、转移等过程密切相关;并且在宫颈病变的发生发展过程中起着重要作用。

Cervical cancer is one of the most common malignant tumors in the female reproductive system, which is mainly caused by high-risk human papillomavirus (human papillomavirus, HPV) infection. From high-risk HPV infection to cervical disease is an extremely complex multi-stage and multigene abnormal regulation process. Long-chain non-coding RNA (long non-coding RNA, LncRNA) is an RNA without coding protein function (>200 nucleotides), but it plays a role in transcription and tran-scription epigenetic level, and is closely related to the occurrence, invasion, metastasis of human cancer;and plays an important role in the occurrence and development of cervical lesions.