基于“肠–肝”轴探讨肝脾同调论治酒精性肝病

Discussion on the Treatment of Alcoholic Liver Disease with Treating Both Liver and Spleen Based on the Theory of “Gut-Liver” Axis

酒精性肝病(Alcoholic liver disease, ALD)是我国的常见疾病,其发病率逐年上升,对人体健康构成严重威胁。“肠–肝”轴理论认为,肠道与肝之间复杂的相互作用影响了ALD的发生及发展,这与中医肝脾同治的理论内涵十分相似。本文分析了“肠–肝”轴与ALD和中医肝脾理论的联系,并结合中药复方探讨肝脾同调论治ALD,以期为临床治疗ALD提供理论基础,为中药研发提供新的思路。

Alcoholic liver disease (ALD) is a common disease in China, the incidence of which is increasing year by year, posing a serious threat to human health. According to the theory of “Gut-liver” axis, the complex interaction between the gut and liver affects the occurrence and development of ALD, which is quite similar to the connotation of the theory of liver and spleen related to traditional Chi-nese medicine. This study analyzed the connection between the theory of “Gut-liver” axis and ALD and the link between the theory of “Gut-liver” axis and the theory of liver and spleen related to tra-ditional Chinese medicine, and discussed the treatment of ALD with Chinese medicine compound based on the theory of treating both liver and spleen, in order to provide a theoretical basis for the clinical treatment of ALD and offer a new thinking for the research and development of traditional Chinese medicine.