lncRNA在骨肉瘤发病机制中的作用

The Role of lncRNA in the Pathogenesis of Osteosarcoma

骨肉瘤是最常见的原发性骨肿瘤类型,主要发生在青少年和年轻人。由于骨肉瘤的恶性程度高,治疗效果差,严重影响了患者的健康和生命。长链非编码RNA (lncRNA)是一类没有或较低蛋白质的编码能力的RNA,可以调节染色质功能以及无膜核体的结构和功能,改变细胞质mRNA的稳定性和翻译,并干扰信号通路。近年来,lncRNA对骨肉瘤的研究报道越来越多,本文对当前较主流的lncRNA对骨肉瘤的作用机制进行了综述。

Osteosarcoma is the commonest type of primary bone tumor, which mainly occurs in adolescents and young people. Due to the high degree of malignancy and poor treatment effect of osteosarcoma, it has seriously affected the health and life of patients. Long chain noncoding RNA (lncRNA) is a kind of RNA with no or low protein coding ability. It can regulate chromatin function and the structure and function of membranous nucleosomes, change the stability and translation of cytoplasmic mRNA, and interfere with signal pathways. In recent years, there are more and more reports on the research of lncrna on osteosarcoma. This paper reviews the mechanism of lncRNA on osteosarcoma.