慢性阻塞性肺疾病急性加重期的血清炎症因子研究

A Study of Serum Inflammatory Factors in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是一种以气流受限不完全可逆为主要特征的肺部疾病,慢阻肺急性加重(AECOPD)是引起COPD患者住院率增高和死亡的重要原因。研究表明AECOPD通常是因为呼吸道感染、空气污染造成局部或全身炎症反应加重,期间会导致多种炎症因子升高。目前AECOPD的诊断主要依靠对患者症状进行评估,目前缺乏敏感客观的诊断指标。本文对AECOPD与血清炎症因子作出简要综述,为未来寻找AECOPD诊断的实验室指标方面提供一定帮助。

Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by incomplete re-versibility of airflow limitation, and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an important cause of increased hospitalization and death in COPD patients. Studies have shown that AECOPD is usually due to an exacerbation of local or systemic inflammatory re-sponses caused by respiratory infections and air pollution, during which a variety of inflammatory factors are elevated. Currently, the diagnosis of AECOPD mainly relies on the evaluation of patients’ symptoms, and there is a lack of sensitive and objective diagnostic indicators. This article provides a brief review of AECOPD and serum inflammatory factors to provide some help in the future search for laboratory indicators for the diagnosis of AECOPD.