背根神经节巨噬细胞调节神经病理性疼痛的潜在作用机制

Macrophage Regulates Neuropathic Pain in Dorsal Root Ganglion: Potential Mechanisms

神经病理性疼痛是神经系统损伤导致的慢性疼痛,它伴有持续的痛觉体验严重影响着患者的生活质量。由于神经性疼痛的发病机制十分复杂,而目前的治疗方法远不能令人满意。因此,探索有效的治疗方法是目前临床中急需解决的问题。背根神经节是感觉传导和调节的重要结构,背根神经节内的巨噬细胞作为外周免疫细胞在神经病理性疼痛中的作用越来越受到重视。背根神经节巨噬细胞与神经元存在双相联系,深入研究外周免疫细胞与外周神经系统的联系,可为治疗各种慢性疼痛提供新思路。本文就背根神经节内巨噬细胞参与神经病理性疼痛的相关分子通路研究进展进行综述。

Neuropathic pain is accompanied by persistent nociceptive experience. As a major consequence, a patient’s quality of life is deeply affected. Neuropathic pain is a chronic pain syndrome with a com-plicated mechanism that currently has no effective therapy. Therefore, it is an urgent problem to further explore an effective treatment for patients with neuropathic pain. The dorsal root ganglion is an important structure for sensory conduction and regulation. It is suggested that macrophage activation in dorsal root ganglia could be involved in neuropathic pain mechanisms. Neurons of dorsal root ganglia interact with macrophages. The link between the peripheral nervous system and immune cells is under intensive investigation and will provide important insights for plausible treatments. In this review, we summarize the underlying molecular mechanisms of macrophages in the dorsal root ganglia involved in neuropathic pain.