外周血炎性指标在新辅助化疗后的三阴性乳腺癌中的临床研究

Clinical Study of Peripheral Blood Inflammatory Indicators in Triple-Negative Breast Cancer after Neoadjuvant Chemotherapy

目的:观察不同外周血炎性指标对三阴性乳腺癌患者新辅助化疗疗效的预测作用以及和临床病理因素的关系。方法:选取青岛大学附属医院2022年1月~2023年1月收治的70例三阴性乳腺癌患者,提取新辅助化疗前外周血中性粒细胞计数、淋巴细胞计数、中性粒细胞/淋巴细胞比例(NLR)、血小板/淋巴细胞比例(PLR)、淋巴细胞/单核细胞比例(LMR),讨论其与临床病理因素及病理完全缓解(pCR)的关系。结果:NLR与年龄和RCB分级密切相关,NLR水平越低,年龄越大,RCB分级越低。PLR水平与MP分级有关,PLR水平越低,MP分级越低。低水平中性粒细胞、低水平NLR与pCR有关。结论:中性粒细胞、NLR可作为预测三阴性乳腺癌新辅助化疗后是否达到pCR的指标。

Objective: To observe the predictive effect of different peripheral blood inflammatory indexes on neoadjuvant chemotherapy in patients with triple-negative breast cancer and the relationship be-tween them and clinicopathological factors. Methods: 70 patients with triple-negative breast cancer admitted to the Affiliated Hospital of Qingdao University from January 2022 to January 2023 were selected. Peripheral blood neutrophil count, lymphocyte count, neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR) and lymphocyte/monocyte (LMR) were extracted before neoadjuvant chemotherapy. Discuss its relationship with clinicopathological factors and pathological complete response (pCR). Results: NLR was closely related to age and RCB grading. The lower the level of NLR, the older the age, the lower the RCB grading. PLR level is related to MP rating, the lower the PLR level, the lower the MP rating. Low levels of neutrophils and low levels of NLR were associated with pCR. Conclusion: Neutrophils and NLR can be used to predict whether pCR is achieved after neoad-juvant chemotherapy for triple-negative breast cancer.