黑素瘤相关肿瘤浸润淋巴细胞的评价方法及免疫异质性研究进展

Research Progress on Evaluation Methods and Immune Heterogeneity of Tumor Infiltrating Lymphocytes in Melanoma

肿瘤浸润淋巴细胞随着免疫治疗的日益兴起,作为一个重要的免疫参数,被证实可以预测免疫治疗的疗效,还可以提示预后。然而迄今为止,没有癌症分期算法包含免疫标记物。重要的是,对TIL浸润的多种成分也缺乏了解。该文综述了肿瘤浸润淋巴细胞在黑素瘤中的评估方法的进展,同时探讨了CD4+T淋巴细胞在黑素瘤中作用的研究进展。

With the rise of immunotherapy, tumor-infiltrating lymphocytes, as an important immune param-eter, have been proved to predict the efficacy of immunotherapy and can also indicate the prognosis. To date, however, no cancer staging algorithm has included immune markers. Importantly, there is also a lack of understanding of the multiple components of TIL infiltration. This article reviews the progress of evaluation methods of tumor-infiltrating lymphocytes in melanoma, and discusses the role of CD4+T lymphocytes in melanoma.