癫痫相关认知功能障碍的研究

Study of Epilepsy-Related Cognitive Dysfunction

癫痫患者经常会发生认知功能障碍。大多数认知问题受到各种相互关联的因素的影响,包括癫痫的早期发作和癫痫发作的频率、强度和持续时间以及抗癫痫药物治疗。成人癫痫患者的大多数认知问题包括记忆力、注意力和执行功能缺陷。然而,哪个认知区域受损很大程度上取决于癫痫活动的位置。此外,信号通路和神经元网络的改变在导致认知障碍的机制中都起着至关重要的作用。同时,研究表明,抗癫痫药物(AEDs)的联合使用会增加认知障碍的风险。然而区分每个因素的贡献可能具有挑战性,因为它们通常紧密交织在一起。因此,本文中我们主要探讨癫痫认知功能的因素,重点从癫痫认知功能的发生机制及不同因素对癫痫认知功能的影响2个方面展开讨论。

Cognitive dysfunction frequently occurs in patients with epilepsy. Most cognitive problems are in-fluenced by a variety of interrelated factors, including the early onset of seizures and the frequency, intensity, and duration of seizures, as well as antiepileptic drug therapy. Most cognitive problems in adults with epilepsy include deficits in memory, attention, and executive function. However, which cognitive region is impaired depends largely on the location of epileptic activity. In addition, altera-tions in both signaling pathways and neuronal networks play a crucial role in the mechanisms leading to cognitive impairment. At the same time, studies have shown that the combination of an-tiepileptic drugs (AEDs) increases the risk of cognitive impairment. Yet distinguishing the contri-bution of each factor can be challenging, as they are often tightly intertwined. Therefore, in this ar-ticle, we focus on the factors of cognitive function in epilepsy, focusing on 2 aspects: the mechanisms of epileptic cognitive function and the effects of different factors on epileptic cognitive function.