慢性阻塞性肺疾病急性加重期治疗的最新进展

The Latest Progress in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是一种异质性、多系统的疾病,受遗传因素和环境因素影响。慢性阻塞性肺疾病急性加重是慢性阻塞性肺疾病患者症状急性恶化、贯穿疾病的自然过程。它不仅导致肺功能下降、心血管事件风险以及生活质量差,而且与重大死亡率和社会经济负担有关。慢性阻塞性肺疾病急性加重是慢性阻塞性肺疾病预后不佳的主要驱动因素。因此它被列为全球死亡和残疾的主要原因。目前临床上慢性阻塞性肺疾病急性加重的治疗策略一直不够充分。慢性阻塞性肺疾病的急性加重代表了一种主要的、未解决的全球健康需求。其在病情恶化时,治疗失败和复发是频繁的,应该仔细评估。本文概述慢性阻塞性肺疾病急性加重患者在整个住院期间实施的个体化治疗方式,以期缓解慢性阻塞性肺病急性加重患者的症状。

Chronic obstructive pulmonary disease (COPD) is a heterogeneous, multisystemic disease that is in-fluenced by genetic and environmental factors. Acute exacerbation of COPD is the natural course of acute worsening of symptoms in people with COPD that occurs throughout the disease. It leads not only to reduced lung function, risk of cardiovascular events and poor quality of life, but is also asso-ciated with significant mortality and socio-economic burden. Acute exacerbation of COPD is a major driver of poor prognosis in COPD. As such it is ranked as a leading cause of death and disability globally. Current clinical treatment strategies for acute exacerbations of COPD have been inade-quate. Acute exacerbations of COPD represent a major, unaddressed global health need. Its treat-ment failures and relapses are frequent as the disease worsens and should be carefully assessed. This article outlines the individualised treatment modalities implemented throughout hospitalisa-tion for patients with acute exacerbations of COPD with the aim of alleviating symptoms in patients with acute exacerbations of COPD.